American Molecules - Ammol.org USA

Celecoxib SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative

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Celecoxib
CAS Number: 169590-42-5

Molecular Formula: C17H14F3N3O2S
Molecular Weight: 381.37

Celecoxib Suppliers
Celecoxib

The MSDS-SDS Hazard Statement of Celecoxib:

Celecoxib SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
13-April-25

Section 1: Product and Company Identification
Product Name & Other Names: Celecoxib.
CAS No.: 169590-42-5
EINECS, EC Number: 685-962-5
Supplier: American Molecules, 9910 Bent Oak Dr, Houston, TX 77040, USA.
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665.
In case of emergency contact: Will be given with the supply.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Eye irritation (Category 2), H319
Reproductive toxicity, (Category 2) H361d
Specific target organ toxicity - repeated exposure (Category 2), H373

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Irritant to eyes
Irritant

GHS Label Elements
Damaging organs and unborn child
Health Hazard

Signal Words: Danger

Hazard statements:
H319: Causes serious eye irritation.
H361d: Suspected of damaging the unborn child.
H373: May cause damage to organs through prolonged or repeated exposure.

Precautionary statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P314: Get Medical advice/attention if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Section 3: Composition / Information on Ingredients

Product Name & Other Names: Celecoxib.
CAS No.: 169590-42-5
EINECS, EC Number: 685-962-5

Section 4: First Aid Measures

Always seek medical attention after first aid measures are provided.

Eyes: Immediately flush your eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse your mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.

Section 5: Fire Fighting Measures

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets as they can scatter fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemicals to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray.
Special hazards arising from the substance: Carbon oxides, Nitrogen oxides (NOx), Sulfur compounds, Fluorine compounds, Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.

Section 6: Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapor, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.

Section 7: Handling and Storage Green

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature. (Recommended in a cool and dark place, <15C). Short-term shipping may be at room temperature.

Section 8: Exposure Controls / Personal Protection

Exposure guidelines: Not Available.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures low.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.

Section 9: Physical and Chemical Properties

Physical state and appearance: White to beige powder.
Odor: No data found.
Odor threshold: No data found.
pH (1% soln/water):No data found.
Relative density: No data found.
Melting Point: 157C to 159C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No information found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Poorly soluble in water.
Viscosity: No data found.

Section 10: Stability and Reactivity

Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat, light, and strong oxidizing agents.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Sulfur compounds, Fluorine compounds, Fumes.
Hazardous Polymerization: Has not been reported.

Section 11: Toxicology Information

LD50 Oral Rat: >2000 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
May causes damage to organs (Kidney) through prolonged or repeated exposure.
Reproductive Effects: Suspected of damaging the unborn child.
Developmental Effects: No data available.
Teratogenicity: No data available.
Inhalation - May cause damage to organs through prolonged or repeated exposure.

Section 12: Ecological Information

Toxicity to daphnia and other aquatic invertebrates: NOEC - Daphnia magna (Water flea) - 0,06 mg/l - 21 Days.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Section 13: Disposal Considerations

Check with all applicable local, regional, and national laws and regulations. Follow all th pollution control laws.

Section 14: Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IATA & IMDG/IMO: Not regulated.

Section 15: Regulatory Information

USA:
SARA 311/312 Hazard Categories
: Acute Health Hazard, Chronic Health Hazard.

Section 16: Other Information

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

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American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.

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Suppliers and Manufacturers' Representative:
American Molecules - Ammol.org USA
9910 Bent Oak Dr
Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665
Email: info@ammol.org

20 April, 2025