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Dorzolamide Hydrochloride SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative |
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Dorzolamide Hydrochloride
CAS Number: 130693-82-2
Molecular Formula: C10H17ClN2O4S3
Molecular Weight: 360.90
Dorzolamide Hydrochloride
Dorzolamide Hydrochloride or Dorzolamide HCl SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 18-Feb-25
Section 1: Product and Company Identification
Product Name & Other Names: Dorzolamide Hydrochloride or Dorzolamide HCl.
CAS No.: 130693-82-2
EINECS, EC Number: 620-304-2
Relevant uses and uses advised against (if any): Laboratory chemicals, Manufacture of substances
Supplier: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Specific target organ toxicity - repeated exposure (Category 2), H373
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
GHS Label Elements |
Signal Words: Danger
Hazard Statements:
H302: Harmful if swallowed.
H373: May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Section 3: Composition / Information on Ingredients
Product Name & Other Names: Dorzolamide Hydrochloride or Dorzolamide HCl.
CAS No.: 130693-82-2
EINECS, EC Number: 620-304-2
Section 4: First Aid Measures
Always seek medical attention after first aid measures are provided.
Eyes: Immediately flush your eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse your mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.
Section 5: Fire Fighting Measures
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets as it can scatter the fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemicals to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray.
Special hazards arising from the substance: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Chlorine compounds.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
Section 6: Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapor, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
Section 7: Handling and Storage Green
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature. Recommended in a cool and dark place, <15C. Refrigeration should be preferred. Short-term shipping may be ambient.
Section 8: Exposure Controls / Personal Protection
Exposure guidelines: Not Available.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
Section 9: Physical and Chemical Properties
Physical state and appearance: Crystalline white to off-white powder.
Odor: No information found.
Odor threshold: No information found.
pH (1% soln/water): No information found.
Relative density: No information found.
Melting Point: 285C literature.
Initial boiling point and boiling range: No information found.
Flash point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor pressure: No information found.
Vapor density: No information found.
Evaporation rate: No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility: Soluble in water.
Viscosity: No information found.
Section 10: Stability and Reactivity
Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat and strong oxidizing agents.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Chlorine compounds.
Hazardous Polymerization: Has not been reported.
Section 11: Toxicology Information
LD50 Oral - Rat - 1927 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
May causes damage to organs (Kidney) through prolonged or repeated exposure.
Reproductive Effects: No No information found.
Developmental Effects: No No information found.
Teratogenicity: No information found.
Section 12: Ecological Information
Toxicity to fish: No information found.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Section 13: Disposal Considerations
Check with all applicable local, regional, and national laws and regulations. Follow all the pollution control rules.
Section 14: Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not Regulated.
IATA & IMDG/IMO: Not Regulated.
Section 15: Regulatory Information
USA:
SARA 311/312 Hazard Categories: See section 2.
California Proposition 65: Not listed to cause cancer, reproductive harm or birth defects.
Section 16: Other Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
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