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Olanzapine SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative |
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Olanzapine
CAS Number: 132539-06-1
Molecular Formula: C17H20N4S
Molecular Weight: 312.44
Olanzapine
Olanzapine SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 2204-Feb-25
1. Product Identification
Product Name & Other Names: Olanzapine.
CAS No.: 132539-06-1
EINECS EC Code: 603-618-4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 3) H301
Skin corrosion (Category 1B) H315
Skin sensitization (Category 1) H317
Eye irritation (Category 2) H319
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements  Toxic |
GHS Label Elements |
Signal Word: Danger
Hazard Statements:
H301: Toxic if swallowed
H315: Causes skin irritation.
H317: May cause an allergic skin reaction
H319: Causes serious eye irritation.
Precautionary Statements
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P301+P310+330: IF SWALLOWED: Rinse mouth and immediately call a POISON CENTER or doctor/physician.
P302+P352: IF ON SKIN: Wash with soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P304+P341+P311: IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P360: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
3. Composition/Information on Ingredients
Product Name & Other Names: Olanzapine.
CAS No.: 132539-06-1
EINECS EC Code: 603-618-4
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Toxic if swallowed. Contact the medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: On contact, it can cause itching, pain, swelling and redness. Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention.
Eye Contact: It can cause severe irritation and harm to eyes. Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Get medical attention.
5. Fire Fighting Measures
Fire: Toxic fumes, sulfur oxides, nitrogen oxide, carbon dioxide and carbon monoxide may be formed in fire.
Explosion: No data available
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide and water spray jet. Avoid solid water jet as it can scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Sweep and shovel and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Toxic. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Keep away from heat and source of fire. Keep in tightly closed container. Storage: Freeze -20C. Short term shipping may be at room temperature. Heat Sensitive.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: Yellow crystalline solid.
Odor: No information found.
Odor threshold: No information found.
pH: No information found.
Relative density: No information found.
Melting Point: 185C to 195C literature.
Initial boiling point and boiling range: 476C literature.
Flash point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor pressure: No information found.
Vapor density: No information found.
Evaporation rate: No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility: Practically insoluble in water.
Viscosity: No information found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Toxic fumes, sulfur oxides, nitrogen oxide, carbon dioxide and carbon monoxide may be formed in fire.
Hazardous Polymerization: Not reported.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flames, moisture, light, ignition sources and incompatibles.
11. Toxicological Information
Oral rat LD50: LD50 Oral Rat: 177 mg/kg.
Dermal rabbit: LD50 Dermal - Rabbit - > 200 mg/kg
Carcinogenicity: Not reported as carcinogen by any agency. No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
Reproductive Toxicity: No information found.
Developmental Effects: No information found.
Teratogenicity: No information found.
12. Ecological Information
Persistence and Degradability: No information found.
Bioaccumulation/ Accumulation: No information found.
Mobility: No information found.
Results of PBT and vPvB assessment: No information found.
Environmental Toxicity: No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.
14. Transport Information
DOT USA & ADR/RID Europe
UN Number: UN 2811
Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (OLANZAPINE)
Class: 6.1, Packing group: III.
IMDG & IATA
UN Number: UN 2811
Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (OLANZAPINE)
Class: 6.1, Packing group: III.
15. Regulatory Information
USA:
SARA 311/312: See section 2.
California Prop 65: Not listed.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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