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Paroxetine Hydrochloride or Paroxetine HCl Anhydrous and Hemihydrate SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative |
Email: info@ammol.org |
Call Toll Free +1-855-552-6665 |
Paroxetine Hydrochloride or Paroxetine HCl
CAS Number: 78246-49-8 or 130855-16-2 or 110429-35-1
Molecular Formula: C19H21ClFNO3
Molecular Weight: 365.82
Paroxetine Hydrochloride or Paroxetine HCl
Paroxetine Hydrochloride or Paroxetine HCl Anhydrous Hemihydrate
SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 01-Feb-25
1. Product Identification
Product Name & Other Names: 78246-49-8 or 130855-16-2 or 110429-35-1.
CAS Number: 2277-92-1
EINECS EC Number: 600-962-7
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral Category 4 - H302
Skin sensitization Category 1 - H317
Eye irritation Category 2 - H319
Specific target organ toxicity - single exposure (Category 3) Respiratory system - H335
Hazardous to the aquatic environment - Chronic Hazard, Category 1- H410
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
GHS Label Elements |
Signal Words: Danger
Hazard Statements:
H302: Harmful if swallowed.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H410: Very toxic to aquatic life with long lasting effects.
Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash contaminated parts thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P314: Get medical advice/attention if you feel unwell.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
3. Composition/Information on Ingredients
Product Name & Other Names: 78246-49-8 or 130855-16-2 or 110429-35-1.
CAS Number: 2277-92-1
EINECS EC Number: 600-962-7
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove affected person to fresh air; if normal breathing has not returned within a few minutes after exposure, get medical attention.
Skin: Remove contaminated clothing; wash affected area with soap and water; launder contaminated clothing before reuse. Seek medical attention.
Eyes: Immediately, flush eyes for 15 minutes in clear running water while holding eyelids open; seek medical attention immediately.
Ingestion: Drink two glasses of water followed by milk, milk of magnesia or other non-alcoholic liquids; Do not induce vomiting; seek medical attention immediately.
5. Fire Fighting Measures
General Hazards: Contact with the eyes causes immediate severe irritation of the eye and eyelids. Product will support combustion.
Extinguishing Media: Carbon dioxide, dry chemical, chemical foam water fog. Do not use a heavy water stream as it can scatter the fire. Keep containers cool by spraying with water. Use extinguishing media appropriate for surrounding fire.
Fire & Explosion Hazard: May evolve oxides of carbon, oxides of nitrogen, chlorine & fluorine compounds, and fumes under fire conditions.
In case of fire, wear a full face positive-pressure self contained breathing apparatus and protective suit. Self - contained respiratory equipment; cool containers to prevent pressure buildup and explosion when exposed to extreme heat.
Unusual Fire and Explosion Hazards: Closed containers can explode due to buildup of pressure when exposed to extreme heat.
Hazardous Combustion Products: Products of combustion include smoke, toxic fumes, oxides of carbon, nitrogen, chlorine & fluorine compounds.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc).
Environmental precautions: Do not let the product enter sewer, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep up and remove to an approved disposal container. It will support combustion. For large spills, confine spill, soak up with approved absorbent, shovel product into approved container for disposal.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Keep containers closed when not in use; protect containers from abuse; protect from extreme temperatures, open flames. This material will support combustion. Storage: Store at room temperature. Preferably refrigerate. Short term shipping may be ambient.
8. Exposure Controls/Personal Protection
Engineering Controls: The use of local exhaust ventilation is recommended to control emissions near the source. Provide mechanical ventilation of confined spaces. Use corrosion-resistant, explosion-proof ventilation equipment.
Exposure Limits: Not listed.
Personal Protection: Respiratory Protection (Specify Type): None required while threshold limits are kept below maximum allowable concentrations; if TWA exceeds standard workplace limits, NIOSH approved respirator must be worn.
Hand Protection: Neoprene, butyl or nitrile rubber gloves with cuffs.
Eye Protection: Chemical safety goggles.
Other Protective Clothing Or Equipment: Apron, or other equipment should be worn to prevent skin contact, safety eyewash station nearby. Practice safe workplace habits.
9. Physical and Chemical Properties
Appearance: White or almost white, hygroscopic, crystalline powder.
Odor: No information found.
Odor threshold: No information found.
pH: No information found.
Relative density: No information found.
Melting point/freezing point: 137C to 139C literature.
Boiling Point: No information found.
Flash point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor Pressure (MM Hg): No information found.
Vapor Density (Air = 1) : No information found.
Evaporation Rate (water = 1): No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility: Insoluble in water. Soluble in DMSO (25 mg/ml), chloroform, and methanol.
Viscosity: No information found.
10. Stability and Reactivity
Stability: Stable at normal temperatures and operating conditions.
Conditions to Avoid: Avoid excessively high temperatures and contact with strong oxidizing agents. Direct sunlight. Air contact.
Incompatibilities: Strong oxidizing agents.
Decomposition: Decomposition yields carbon oxides, chlorine & fluorine compounds, nitrogen oxides and fumes.
Polymerization: Polymerization will not occur.
11. Toxicological Information
Acute toxicity:
Acute toxicity estimate Oral – 500.1 mg/kg.
Carcinogenicity: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, NIT, ACGIH or OSHA.
Mutagenic Effects: No information found.
Teratogenic Effects: No information found.
Developmental Toxicity: No information found.
Reproductive Effects: No information found.
12. Ecological Information
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - 6,24 mg/l - 48 h.
Persistence and Degradability: No information found.
Mobility: No information found.
Bioaccumulation/ Accumulation: No information found.
Results of PBT and vPvB assessment: No data found for assessment.
13. Disposal Considerations
Dispose of it in accordance with Local, State, and Federal Regulations. Consult local, state, or Federal Environmental Protection Agency before disposing of any chemicals.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe:
UN number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Paroxetine hydrochloride).
Hazard class(es) 9; Packing group: III.
IMDG/IMO:
UN number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Paroxetine hydrochloride).
Hazard class(es) 9; Packing group: III.
ICAO/IATA:
UN number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Paroxetine hydrochloride).
Hazard class(es) 9; Packing group: III.
15. Regulatory Information
No additional information is available.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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