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Teriflunomide SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative |
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Teriflunomide
CAS Number: 163451-81-8 or 108605-62-5
Molecular Formula: C12H9F3N2O2
Molecular Weight: 270.21
Teriflunomide
Teriflunomide SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 02-Feb-25
1. Product Identification
Product Name & Other Names: Teriflunomide.
CAS No.: 163451-81-8 or 108605-62-5
EINECS EC Number: 642-273-4 or 685-149-5
Relevant uses and uses advised against (if any): Industrial Manufacturing
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4 (H302)
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
Signal Words: Warning.
Hazard statements:
H302 Harmful if swallowed.
Precautionary statements:
P264: Wash --- thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352: IF ON SKIN: Wash with soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
3. Composition/Information on Ingredients
Product Name & Other Names: Teriflunomide.
CAS No.: 163451-81-8 or 108605-62-5
EINECS EC Number: 642-273-4 or 685-149-5
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact a poison control center or physician for treatment advice. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Flammability of the Product: Non-flammable. However, it can burn at high temperature.
Products of Combustion: During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Hydrogen fluoride, Nitrogen oxides carbon oxides and fumes can be formed.
Fire Extinguishing Media: Use water spray or fog for cooling exposed containers. Fine water spray, normal foam, dry agent (carbon dioxide, dry chemical powder) can be used. Exercise caution when fighting any chemical fire. Avoid solid water jets as they can scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill: Contain spilled material. Avoid touching the spilled material. Do not let the product enter drains. Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Toxic if swallowed. Do not ingest. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Provide appropriate exhaust ventilation at places where dust is formed. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatibles like oxidizing agents. Storage: Refrigerator. Preferably freezer.-20C. Heat Sensitive. Short term shipping may be ambient.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: No data found.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White to almost white powder or crystals.
Odor: No information found.
Odor threshold: No information found.
pH: No information found.
Relative density: No information found.
Boiling Point: No information found.
Melting Point: 227C to 231C literature.
Flash point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor pressure: No information found.
Vapor density: No information found.
Evaporation rate: No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility: Soluble in DMSO.
Viscosity: No information found.
10. Stability and Reactivity
Stability: Stable under recommended conditions of use and storage.
Hazardous Decomposition Products: Hydrogen fluoride, Nitrogen oxides carbon oxides and fumes can be formed.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Incompatibles. Avoid Heat & incompatibles.
11. Toxicological Information
Toxicity data
LD50 Oral - Rat – 500.1 mg/kg
Carcinogenic Effects: Not known to be a carcinogen by IARC NTP ACGIH OSHA.
Mutagenic Effects: No information found.
Teratogenic Effects: No information found.
Developmental Toxicity: No information found.
12. Ecological Information
Toxicity to fish: No information found.
Persistence and Degradability: No information found.
Mobility: No information found.
Bioaccumulation/ Accumulation: No information found.
Results of PBT and vPvB assessment: No information found for assessment.
13. Disposal Considerations
Follow all the governmet rules and regulation. Do not violate the pollution control rules.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe : Not regulated.
IATA: Not regulated.
IMDG/IMO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312: See section 2.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Please visit Main Page of Teriflunomide Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
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Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665
Email: info@ammol.org