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Hydroxyethyl Starches
CAS Number: 9005-27-0
Hydroxyethyl Starches
Different types of hydroxyethyl starches are typically described by their average molecular weight, typically around 130 to 200 kDa. Storage: 2C to 8C.
Hydroxyethyl Starches BP Ph Eur Grade:
C6H10O5(C2H4O)] with x = molar substitution CAS 9005-27-0
DEFINITION
Hydroxyethyl starches are partially substituted poly(2-hydroxyethyl)ethers of waxy maize starch or potato starch, which primarily consist of amylopectine. The type of hydroxyethyl starch is defined by 2 numbers: the mean molecular weight (Mw) and the number of hydroxyethyl groups per anhydroglucose unit expressed as the molar substitution (MS). Hydroxyethyl starch is also characterised by the number of hydroxyethyl groups located at the C2 group over the number of hydroxyethyl groups located at C6, expressed as the C2/C6 ratio. The parameters Mw, MS and C2/C6 ratio are determined by the reaction conditions of the production.
PRODUCTION
Hydroxyethyl starches are produced from waxy maize starch or potato starch by acidic hydrolysis and reaction with ethylene oxide and purified by ultrafiltration.
CHARACTERS
Appearance: White or almost white powder.
Solubility: Freely soluble in water and in dimethyl sulfoxide, practically insoluble in anhydrous ethanol.
Hydroxyethyl starches are hygroscopic until they reach a water content of about 12 per cent to 15 per cent.
IDENTIFICATION
First identification: A, C
Second identification: B, C
A. Infrared absorption spectrophotometry.
B. To 5 mL of solution S (see Tests), add 0.1 mL of 0.05 M iodine. A reddish-brown or blue violet colour appears.
C. Molecular weight: To pass the test.
TESTS
Solution S: Dissolve 5.0 g of the substance to be examined (dried substance) in carbon dioxide-free water and dilute to 100.0 mL with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension II.
pH: 4.5 to 7.0.
To 25 mL of solution S, add 0.2 mL of a saturated solution of potassium chloride R.
Absorbance: Maximum 0.025, determined at 400 nm on solution S filtered through a 0.2 µm filter.
Molecular weight (Mw) and molecular weight distribution: To pass the test.
C2/C6 ratio: Specified Test.
Molar substitution (MS): 0.05 to 2.4, and within 8.0 % of the nominal value.
Ethylene glycol: Not more than 40 ppm.
2-Chloroethanol: Not more than 5 ppm.
Ethylene oxide: Not more than 1 ppm.
Sodium chloride: Maximum 0.1 %
Loss on drying: Maximum 15.0 %.
Please visit SDS Safety Data Sheet of Hydroxyethyl Starches Suppliers.
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