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Melfalan or Melphalan SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative |
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Melfalan or Melphalan
CAS Number: 148-82-3
Molecular Formula: C13H18Cl2N2O2
Molecular Weight: 305.20
Melfalan or Melphalan
Melphalan or Melfalan SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 22-Jan-25
Section 1. Product Information
Product Name/Trade Name: Melphalan or Melfalan.
CAS No.: 148-82-3
EINECS EC Number: 205-726-3
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 2), H300
Skin sensitization (Category 1), H317
Germ cell mutagenicity (Category 1A), 1B, H340
Carcinogenicity (Category 1A), H350
Reproductive toxicity (Category 2), H361
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements  Health Hazard |
GHS Label Elements |
Signal Words: Danger
Hazard statements:
H300 Fatal if swallowed.
H317 May cause an allergic skin reaction.
H340 May cause genetic defects.
H350 May cause cancer.
H361 Suspected of damaging fertility or the unborn child.
Precautionary statements:
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P270: Do not eat, drink, or smoke when using this product.
P281: Use personal protective equipment as required.
P330: Rinse mouth.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P405: Store locked up.
Section 3: Composition and Information on Ingredients
Product Name/Trade Name: Melphalan or Melfalan.
CAS No.: 148-82-3
EINECS EC Number: 205-726-3
Chemical Formula: C13H18Cl2N2O2
Section 4. First Aid & Procedure
Always get medical attention after the first aid is over.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin: Immediately flush skin with plenty of water for at least 15 minutes. Get medical attention if irritation develops.
Eyes: Immediately flush eyes with plenty of water for 15 minutes, occasionally lifting upper and lower eyelids. Get medical attention.
Inhalation: Remove person to fresh air. If breathing is difficult, give oxygen. If not breathing administer artificial respiration. Get medical attention.
Section 5. Fire Fighting Measures
Fire/Explosion: Not considered to be a fire and explosion hazard. However, it can burn at high temperature.
Extinguishing Medium: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it may scatter the fire.
Special hazards arising from the substance or mixture: Chlorine compounds, Carbon oxides & Nitrogen oxides, Fumes may evolve.
Fire Fighting Instructions: Use suitable protective equipment for surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
Section 6. Spills and Disposals
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
Section 7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Refrigerated. Sensitive to light, heat, and moisture. Short term shipping may be ambient.
Section 8. Exposure Controls & Personal Protection
Exposure Limits: This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Engineering Controls: Use adequate exhaust ventilation to keep airborne concentrations LOW.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
Section 9. Physical & Chemical Data
Physical State: White to buff-colored powder.
Odor: Odorless or with a faint odor.
Odor threshold: No information found.
pH: No information found.
Relative density: No information found.
Melting Point: 180C to 183C literature.
Initial boiling point and boiling range: No information found.
Flash point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor pressure: No information found.
Vapor density: No information found.
Evaporation rate: No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility in water: No information found.
Viscosity: No information found.
Section 10. Stability and Reactivity
Chemical Stability: Stable under recommended temperatures and pressures.
Incompatibility (Materials to Avoid): Oxidizing agents. Sensitive to light, heat, and moisture.
Conditions to Avoid: Incompatible materials, exposure to moist air or water, excessive heat, and light.
Hazardous Decomposition Products: Chlorine compounds, Carbon oxides, Nitrogen oxides, Fumes.
Hazardous Polymerization: Will not occur.
Section 11. Toxicological Information
Toxicity to Animals: LD50 Oral - Rat - 26 mg/kg.
Carcinogenicity: Group 1. Carcinogenicity to humans.
Specific target organ toxicity: May cause genetic defects. Fatal if swallowed. Suspected human reproductive toxicant.
Section 12. Ecological Information
Ecotoxicity: No information found.
Persistence and Degradability: No information found.
Mobility: No information found.
Bioaccumulation/ Accumulation: No information found.
Results of PBT and vPvB assessment: No information found for assessment.
Environmental Precautions: DO NOT DISCHARGE into drains and rivers.
Section 13. Disposal Suggestions
Dispose of in accordance with all applicable local, state, and federal regulations at an approved waste disposal facility. Follow all the pollution control rules.
Section 14. Transport and Label Information
DOT USA, TDG Canada & ADR/RID Europe:
UN number: 2811
Hazard class: 6.1; Packing group: II
Proper shipping name: Toxic solid, organic, n.o.s. (Melphalan).
IMDG/IMO:
UN number: 2811
Hazard class: 6.1; Packing group: II
Proper shipping name: Toxic solid, organic, n.o.s. (Melphalan).
IATA:
UN number: 2811
Hazard class: 6.1; Packing group: II
Proper shipping name: Toxic solid, organic, n.o.s. (Melphalan).
Section 15. Regulatory Information
USA:
SARA 311/312: See section 2.
California Prop.65: WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.
Section 16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
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