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Melfalan or Melphalan
CAS Number: 148-82-3
Molecular Formula: C13H18Cl2N2O2
Molecular Weight: 305.20
Melfalan or Melphalan
Melphalan or Melfalan is used as a chemotherapy medication. It is used in the treatment of multiple myeloma, advanced ovarian adenocarcinoma, early and advanced breast cancer, childhood neuroblastoma, and polycythaemia vera.
General Properties and Specifications of Melphalan or Melfalan:
Appearance: White to buff-colored powder.
Assay: 96%
Odor: Odorless or with a faint odor.
Melting Point: 180C to 183C literature.
Solubility: Practically insoluble in water.
Storage: Refrigerated. Sensitive to light, heat, and moisture. Short term shipping may be ambient.
Melphalan USP Grade Specifications:
C13H18Cl2N2O2 --- 305.20
l-Phenylalanine, 4-bis(2-chloroethyl)amino]-.
l-3-[ p-[Bis(2-chloroethyl)amino]phenyl]alanine
CAS 148-82-3
UNII: Q41OR9510P
Melphalan contains not less than 93.0 percent and not more than 100.5 percent of C13H18Cl2N2O2 calculated on the dried and ionizable chlorine-free basis.
Packaging and storage: Preserve in tight, light-resistant, glass containers.
Identification:
A: Ultraviolet Absorption
B: To 1 mL of 1 in 10,000 solution in alcohol in a glass-stoppered test tube add 1 mL of pH 4.0 acid phthalate buffer, 1 mL of a 1 in 20 solution of 4-(p-nitrobenzyl)pyridine in acetone, and 1 mL of saline TS. Heat on a water bath at 80C for 20 minutes, and cool quickly. Add 10 mL of alcohol and 1 mL of 1 N potassium hydroxide: a violet to red-violet color is produced.
C: Heat 100 mg with 10 mL of 0.1 N sodium hydroxide on a water bath for 10 minutes: the resulting solution, after acidification with 2 N nitric acid, responds to the tests for Chloride.
Specific rotation: between −30° and −36°.
Test solution: 7 mg per mL, in methanol, prepared with the aid of gentle heating.
Loss on drying: Dry it in vacuum at 105C to constant weight: it loses not more than 7.0% of its weight.
Residue on ignition: not more than 0.3%.
Ionizable chlorine: To pass the test.
Nitrogen Determination: To pass the test. Not less than 8.90% and not more than 9.45% of N is found, calculated on the dried basis.
Melphalan is available in BP Ph Eur EP Grade as per latest monograph.
Please visit SDS Safety Data Sheet of Melfalan or Melphalan Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
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Houston, TX 77040, USA
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