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Poloxamer 124, 188, 237, 331, 338, 407 USP FCC Food Grade Supplier Exporter Manufacturers' Representative |
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Poloxamer 124, 188, 237, 331, 338, 407
CAS Number: 9003-11-6
Molecular Formula: HO(C2H4O)a(C3H6O)b(C2H4O)aH
Molecular Weight: Varies
Poloxamer 124, 188, 237, 331, 338, 407
Specifications of Poloxamer USP NF Grade:
HO(C2H4O)a(C3H6O)b(C2H4O)aH
Polyethylene-polypropylene glycol --- CAS 9003-11-6
DEFINITION
Poloxamer is a synthetic block copolymer of ethylene oxide and propylene oxide. It is available in several types, conforming to the requirements shown in the following table.
| Poloxamer --- Physical Form --- Avg M. Wt. | Wt. (% Oxyethylene) | Unsaturation (mEq/g) |
| 124 ----------- Liquid ---------- 2090–2360 | 46.7 ± 1.9 | 0.020 ± 0.008 |
| 188 ----------- Solid ----------- 7680–9510 | 81.8 ± 1.9 | 0.026 ± 0.008 |
| 237 ----------- Solid ----------- 6840–8830 | 72.4 ± 1.9 | 0.034 ± 0.008 |
| 338 ----------- Solid -----------12700– 17400 | 83.1 ± 1.7 | 0.031 ± 0.008 |
| 407 ----------- Solid ----------- 9840–14600 | 73.2 ± 1.7 | 0.048 ± 0.017 |
IDENTIFICATION
A. Infrared Absorption: Use a thin film of melted specimen if it is a solid. Use USP Poloxamer Liquid for Poloxamer 124, and use USP Poloxamer Solid for Poloxamer 188, 237, 338, and 407. Because of the differences in the ratios of copolymer composition, the intensity of some absorption bands may vary.
ASSAY
Average Molecular Weight:
To pass the test.
Acceptance criteria: See the table in the Definition.
Weight Percent Oxyethylene:
To pass the test.
Acceptance criteria: See the table in the Definition.
Unsaturation:
To pass the test.
Acceptance criteria: See the table in the Definition.
Limit of Free Ethylene Oxide, Propylene Oxide, and 1,4-Dioxane:
To pass the test by Chromatography.
Acceptance criteria:
Ethylene oxide: NMT 1 micro-g/g
Propylene oxide: NMT 5 micro-g/g
1,4-Dioxane: NMT 5 micro-g/g
pH: 5.0–7.5, in a solution (1 in 40)
Specifications of Poloxamer 407 FCC Food Grade:
αHydro-omega-hydroxy-poly(oxyethylene)-poly(oxypropylene)(63-71 moles)poly(oxyethylene) Block Copolymer
Formula weight: (average) 12,500
DESCRIPTION
Poloxamer 407 occurs as a white solid. It is a copolymer condensate of ethylene oxide and propylene oxide with a melting range of about 52C to 56C. It is freely soluble in alcohol and in water but is insoluble in propylene glycol and in ethylene glycol.
Function: Solubilizing and stabilizing agent in flavor concentrates.
REQUIREMENTS
Cloud Point of a 1:10 Solution: Above 100C.
Ethylene Oxide, Propylene Oxide, and 1,4-Dioxane: Not more than 5 mg/kg of each.
Hydroxyl Value: Between 8.5 and 11.5.
Lead: Not more than 2 mg/kg.
Molecular Weight: Between 9760 and 13,200.
pH of a 2.5% Solution: Between 6.0 and 7.4.
Specifications of Poloxamer 331 FCC Food Grade:
αHydro-omega-hydroxy-poly(oxyethylene)-poly(oxypropylene)(51-57 moles)poly(oxyethylene) Block Copolymer
Formula weight: (average) 3800
DESCRIPTION
Poloxamer 331 occurs as a practically colorless liquid. It is a block copolymer condensate of ethylene oxide and propylene oxide with an average formula weight of 3800, a specific gravity of about 1.02, and a refractive index of about 1.452. It is very slightly soluble in water at 25C but is freely soluble at 0C; it is freely soluble in alcohol but is insoluble in propylene glycol and in ethylene glycol.
Function: Solubilizing and stabilizing agent in flavor concentrates.
REQUIREMENTS
Cloud Point of a 1:10 Solution: Between 9C and 12C.
Ethylene Oxide, Propylene Oxide, and 1,4-Dioxane: Not more than 5 mg/kg of each.
Hydroxyl Value: Between 27.2 and 32.1.
Lead: Not more than 2 mg/kg.
Molecular Weight: Between 3500 and 4125.
pH of a 2.5% Solution: Between 6.0 and 7.4.
We also supply Poloxamer BP Ph Eur Grade.
Please visit SDS Safety Data Sheet of Poloxamer 124, 188, 237, 331, 338, 407 Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
9910 Bent Oak Dr
Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665
Email: info@ammol.org