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Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate USP NF Grade Supplier Exporter Manufacturers' Representative |
Email: info@ammol.org |
Call Toll Free +1-855-552-6665 |
Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate
CAS Number: 71138-97-1
Molecular Formula: C10H22O9
Molecular Weight: 286.28
Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate
Specifications of Hypromellose Acetate Succinate USP NF Grade:
Hydroxypropyl methylcellulose acetate succinate;
Cellulose, 2-hydroxypropyl methyl ether, acetate hydrogen butanedioate;
Cellulose, 2-hydroxypropyl methyl ether, acetate succinate --- CAS 71138-97-1
DEFINITION
Hypromellose Acetate Succinate is a mixture of acetic acid and monosuccinic acid esters of hydroxypropyl methylcellulose. It contains NLT 12.0% and NMT 28.0% of methoxy groups (– OCH3 ), NLT 4.0% and NMT 23.0% of hydroxypropoxy groups (– OCH2CHOHCH3 ), NLT 2.0% and NMT 16.0% of acetyl groups (– COCH3 ), and NLT 4.0% and NMT 28.0% of succinoyl groups (– COC2H4COOH), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption:
To pass the test.
Acceptance criteria: The IR spectrum of the Sample exhibits maxima only at the same wavelengths as a similarly obtained spectrum of USP Hypromellose Acetate Succinate.
ASSAY
Acetyl and Succinoyl Groups:
To pass the test by Chromatography
Acceptance criteria:
Acetyl groups (– COCH3 ): 2.0%–16.0% on the dried basis
Succinoyl groups (– COC2H4COOH): 4.0%–28.0% on the dried basis
Content of Methoxy and 2-Hydroxypropoxy Groups:
To pass the test by Chromatography
Acceptance criteria
Methoxy groups (– OCH3 ): 12.0%–28.0% on the dried basis
Hydroxypropoxy groups (– OCH2CHOHCH3 ): 4.0%–23.0% on the dried basis
Residue on Ignition:
Analysis: Determine at 600 ± 50C.
Acceptance criteria: NMT 0.20%
Limit of Free Acetic and Succinic Acids:
To pass the test.
Acceptance criteria: The sum of free acetic acid and free succinic acid is NMT 1.0%.
Loss on Drying:
Analysis: Dry at 105C for 1 h.
Acceptance criteria: NMT 5.0%
Viscosity—Capillary Methods:
To pass the test.
Acceptance criteria: 80%–120% of that stated on the label.
Please visit SDS Safety Data Sheet of Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
9910 Bent Oak Dr
Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665
Email: info@ammol.org