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Calcium Glucono Lactobionate or Calcium Glubionate Powder and Syrup USP Grade Supplier Exporter Manufacturers' Representative |
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Calcium Glucono Lactobionate or Calcium Glubionate Powder and Syrup
CAS Number: 12569-38-9
Molecular Formula: (C12 H21 O12-C6 H11 O7) Ca-2H2O
Molecular Weight: 592.51 (anhydrous)
Calcium Glucono Lactobionate or Calcium Glubionate Powder and Syrup
Specifications of Powder Calcium Glubionate or Calcium Glucono Lactobionate or Glubionate calcium
Description: White to yellow-tinged crystalline granules or powder.
Clarity & Color of Solution: 10 % W/V solution is clear and colorless.
Solubility: Freely soluble in water, very slightly soluble in alcohol.
Loss on drying: Not more than 5%
pH of 10% solution @ 25C: 5.4 to 8
Sulfate: Not more than 400 ppm.
Chlorides: Not more than 500 ppm.
Heavy Metals: Not more than 20 ppm.
Arsenic: Not more than 2 ppm.
Iron: Not more than 40 ppm.
Calcium Content: 6.0 % to 7.0 %.
Calcium Glubionate Syrup USP Grade:
Calcium Glubionate Syrup is a solution containing equimolar amounts of Calcium Gluconate and Calcium Lactobionate or with Calcium Lactobionate predominating. It contains not less than 95.0 percent and not more than 105.0 percent of the labeled amount of calcium (Ca).
A: A dilution of the Syrup with water (1 in 10) responds to the tests for Calcium.
B: Dilute a portion of the Syrup with water to obtain a test solution containing about 0.4 mg of calcium per mL. Prepare a Standard solution in water containing 2 mg of calcium gluconate and 4 mg of calcium lactobionate per mL. Apply separately 5 0L of the test solution and 5 0L of the Standard solution to a suitable thin-layer chromatographic plate coated with 0.25-mm layer of chromatographic silica gel (see Chromatography 621 ). Dry the plate in a current of cool air. Place the plate in a suitable chromatographic chamber lined with filter paper and previously equilibrated with a solvent system consisting of a mixture of alcohol, water, ethyl acetate, and ammonium hydroxide (50:30:10:10). Develop the chromatogram until the solvent front has moved about three-fourths of the length of the plate. Remove the plate from the chamber, and dry at 100 for 20 minutes. Allow to cool, and spray with a spray reagent prepared as follows: Dissolve 2.5 g of ammonium molybdate in about 50 mL of 2 N sulfuric acid in a 100-mL volumetric flask, add 1.0 g of ceric sulfate, swirl to dissolve, dilute with 2 N sulfuric acid to volume, and mix. Heat the plate at 110 for about 10 minutes: the two principal spots obtained from the test solution correspond in color, size, and RF value to those obtained from the Standard solution. [NOTE—Sucrose, if present in the test solution, appears in the chromatogram as a spot between two principal spots.]
pH: between 3.4 and 4.5.
Assay: Transfer an accurately measured portion of Syrup, equivalent to about 70 mg of Ca, to a suitable beaker. Add 2 mL of 3 N hydrochloric acid, and dilute with water to about 150 mL. While stirring with a magnetic stirrer, add about 20 mL of 0.05 M edetate disodium from a 50-mL buret. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and continue the titration to a blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to 2.004 mg of calcium (Ca).
Please visit SDS Safety Data Sheet of Calcium Glucono Lactobionate or Calcium Glubionate Powder and Syrup Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
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