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Dexpanthenol or Pantothenol or D-Panthenol or D-Pantothenyl Alcohol or Vitamin B5
CAS Number: 81-13-0 or 16485-10-2
Molecular Formula: C9H19NO4
Molecular Weight: 205.25
Dexpanthenol or Pantothenol or D-Panthenol or D-Pantothenyl Alcoholor Vitamin B5
D-Panthenol (also called dexpanthenol or provitamin B5) is the biologically active alcohol derivative of vitamin B5. It is widely used in skin and hair care products because it deeply hydrates, calms irritation, and helps repair the skin barrier.
Dexpanthenol USP Grade Specifications:
C9H19NO4 --- 205.25
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-;
d-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
CAS 81-13-0
UNII: 1O6C93RI7Z
DEFINITION
Dexpanthenol contains NLT 98.0% and NMT 102.0% of dexpanthanol (C9H19NO4), calculated on the anhydrous basis.
IDENTIFICATION
A. Infrared Absorption
B.
Sample solution: 100 mg/mL of Dexpanthenol.
Analysis: To 1 mL of the Sample solution add 5 mL of 1 N sodium hydroxide and 1 drop of cupric sulfate and shake vigorously.
Acceptance criteria: A deep blue color develops.
C.
Sample solution: 10 mg/mL of Dexpanthenol.
Analysis: To 1 mL of the Sample solution add 1 mL of 1 N hydrochloric acid, and heat on a steam bath for 30 min. Cool, add 100 mg of hydroxylamine hydrochloride, and add 5 mL of 1 N sodium hydroxide. Allow to stand for 5 min, then adjust with 1 N hydrochloric acid to a pH of 2.5 to 3.0 and add 1 drop of ferric chloride.
Acceptance criteria: A purplish red color develops.
Residue on Ignition: NMT 0.1%
Limit of Aminopropanol: To pass the test.
Optical Rotation, Specific Rotation:
Sample solution: 50 mg/mL in water.
Acceptance criteria: +29.0° to +31.5°
Refractive Index: 1.495–1.502, at 20C
Water Determination: NMT 1.0%
Packaging and Storage: Preserve in tight containers.
Dexpanthenol FCC Food Grade Specifications:
D(+)-Pantothenyl Alcohol; Panthenol
C9H19NO4 Formula weight 205.25
CAS 81-13-0
DESCRIPTION
Dexpanthenol occurs as a clear, viscous, somewhat hygroscopic liquid. It is the dextrorotatory isomer of the alcohol analogue of pantothenic acid. Some crystallization may occur on standing. It is freely soluble in water, in alcohol, in methanol and in propylene glycol. It is soluble in chloroform and in ether and is slightly soluble in glycerin. Its solutions are alkaline to litmus.
Function: Nutrient.
REQUIREMENTS
Identification:
A. Add 5 mL of 1 N sodium hydroxide and 1 drop of cupric sulfate to 1 mL of a 10% aqueous solution and shake vigorously. Deep-blue color develops.
B. Add 1 mL of 1 N hydrochloric acid to 1 mL of a 1% aqueous solution, and heat on a steam bath for about 30 minutes. Cool, add 100 mg of hydroxylamine hydrochloride, mix, and add 5 mL of 1 N sodium hydroxide. Allow it to stand for 5minutes, then adjust the pH to within a range of 2.5 to 3.0 with 1 N hydrochloric acid and add 1 drop of ferric chloride. A purple-red color develops.
C. The infrared absorption spectrum of a film of the sample exhibits maxima only at the same wavelengths as those of a similar preparation of USP Dexpanthenol Reference Standard.
Assay: Not less than 98.0% and not more than 102.0% of C9H19NO4, calculated on the anhydrous basis.
Aminopropanol: Not more than 1%.
Lead: Not more than 5 mg/kg.
Optical (Specific) Rotation [α]D25°: Between +29.0° and +31.5°.
Refractive Index: Between 1.495 and 1.502 at 20°.
Residue on Ignition: Not more than 0.1%.
Water: Not more than 1%.
Dexpanthenol or Pantothenol or D-Panthenol or D-Pantothenyl Alcoholor is also offered as BP Ph Eur IP Grade as per the monograph.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
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