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Fumed Silica or Colloidal Silicon Dioxide and Precipitated Silica
CAS Number: 112945-52-5 or 7631-86-9 or 63231-67-4 and 112926-00-8
Molecular Formula: SiO2
Molecular Weight: 60.08
Fumed Silica or Colloidal Silicon Dioxide and Precipitated Silica
Silicon dioxide is generally recognized as safe by the FDA. In the pharmaceutical industry, colloidal silicon dioxide is used in tablet-making, including use as an anti-caking agent, adsorbent, disintegrant, or glidant to allow powder to flow freely when tablets are processed.
Fumed silica also known as pyrogenic silica is a very fine particulate or colloidal form of silicon dioxide. It is prepared by burning SiCl4 in an oxygen-rich hydrogen flame to produce a "smoke" of SiO2.
Hydrophilic fumed silica is used with increasing success in high technology fields including pharmaceuticals, polyester, silicone, paints and coatings.
Hydrophobic fumed silica has a low moisture adsorption, excellent dispersibility, and ability to adjust rheological behavior, even that of polar systems.
Precipitated silica is an amorphous form of silica. It is a white, powdery material, produced by precipitation from a solution containing silicate salts. We offer it in various bulk density.
Specifications of Colloidal Silicon Dioxide USP NF Grade:
SiO2 --- 60.08
This is a fumed silica grade.
Silica CAS 7631-86-9
Colloidal Silicon Dioxide is a submicroscopic fumed silica prepared by the vapor-phase hydrolysis of a silicon compound. When ignited at 1000 for 2 hours, it contains not less than 99.0 percent and not more than 100.5 percent of SiO2.
Identification:
A: Transfer about 5 mg to a platinum crucible and mix with about 200 mg of anhydrous potassium carbonate. Ignite at a red heat over a burner for about 10 minutes, and cool. Dissolve the melt in 2 mL of freshly distilled water, warming if necessary, and slowly add 2 mL of ammonium molybdate to the solution: a deep yellow color is produced.
B: [Caution: Avoid contact with o-tolidine when performing this test, and conduct the test in a wellventilated hood.] Place 1 drop of the yellow silicomolybdate solution obtained in Identification test A on a filter paper and evaporate the solvent. Add 1 drop of a saturated solution of o-tolidine in glacial acetic acid to reduce the silicomolybdate to molybdenum blue, and place the paper over ammonium hydroxide: a greenish blue spot is produced.
pH: between 3.5 and 5.5, in a 1 in 25 dispersion.
Loss on drying: Dry it in a tared platinum crucible at 105 for 2 hours: it loses not more than 2.5% of its weight. Retain the dried specimen, in the crucible, for the test for Loss on ignition.
Loss on ignition: Ignite the portion of Colloidal Silicon Dioxide, retained from the test for Loss on drying, at 1000C ± 25C to constant weight: the previously dried Colloidal Silicon Dioxide loses not more than 2.0% of its weight.
Arsenic: To pass the test. The limit is 8 microg per g.
Assay: Transfer about 500 mg of Colloidal Silicon Dioxide to a tared platinum crucible, ignite at 1000C ± 25C for 2 hours, cool in a desiccator, and weigh. Add 3 drops of sulfuric acid and add enough alcohol to just moisten the sample completely. Add 15 mL of hydrofluoric acid, and in a well-ventilated hood evaporate on a hot plate to dryness, using medium heat (95C to 105C) and taking care that the sample does not spatter as dryness is approached. Heat the crucible to a red color with the aid of a Bunsen burner. Ignite the residue at 1000 ± 25 for 30 minutes, cool in a desiccator, and weigh. If a residue remains, repeat the procedure, beginning with “add 15 mL of hydrofluoric acid.” The weight lost by the assay specimen, previously ignited at 1000C± 25C, represents the weight of SiO2 in the portion taken.
Specifications of Silicon Dioxide USP NF Grade:
This is a precipitated silica grade.
SiO2xH2O
Anhydrous 60.08
Silicon Dioxide is obtained by insolubilizing the dissolved silica in sodium silicate solution. Where obtained by the addition of sodium silicate to a mineral acid, the product is termed silica gel; where obtained by the destabilization of a solution of sodium silicate in such manner as to yield very fine particles, the product is termed precipitated silica. After ignition at 1000C for not less than 1 hour, it contains not less than 99.0 percent of SiO2.
Labeling: Label it to state whether it is silica gel or precipitated silica.
Identification: Transfer about 5 mg to a platinum crucible, mix with about 200 mg of anhydrous potassium carbonate, ignite at a red heat over a burner for 10 minutes and cool. Dissolve the melt in 2 mL of recently distilled water, warming if necessary, and slowly add 2 mL of ammonium molybdate: a deep yellow color is produced.
pH: between 4 and 8, in a slurry (1 in 20).
Loss on drying: Dry it at 145 for 4 hours: it loses not more than 5.0% of its weight.
Loss on ignition: Ignite about 1 g of it, previously dried and accurately weighed, at 1000C for not less than 1 hour: it loses not more than 8.5% of its weight.
Chloride: Boil 5 g in 50 mL of water under a reflux condenser for 2 hours, cool, and filter. A 7-mL portion of the filtrate shows no more chloride than corresponds to 1.0 mL of 0.020 N hydrochloric acid (0.1%).
Sulfate: A 10-mL portion of the filtrate obtained in the test for Chloride shows no more sulfate than corresponds to 5.0 mL of 0.020 N sulfuric acid (0.5%).
Arsenic: To pass the test. --- The limit is 3 ppm.
Heavy metals: To pass the test. --- The limit is 0.003%.
Assay: Transfer about 1 g of Silica Gel to a tared platinum dish, ignite at 1000 for 1 hour, cool in a desiccator, and weigh. Carefully wet with water, and add about 10 mL of hydrofluoric acid, in small increments. Evaporate on a steam bath to dryness, and cool. Add about 10 mL of hydrofluoric acid and about 0.5 mL of sulfuric acid and evaporate to dryness. Slowly increase the temperature until all of the acids have been volatilized and ignite at 1000C. Cool in a desiccator, and weigh. The difference between the final weight and the weight of the initially ignited portion represents the weight of SiO2.
Hydrophobic Colloidal Anhydrous Silica BP Ph Eur Grade is also supplied:
DEFINITION
Colloidal silicon dioxide partly alkylated for hydrophobation.
Content: 99.0 per cent to 101.0 per cent SiO2 (ignited substance).
Colloidal Anhydrous Silica BP Ph Eur Grade is also supplied:
SiO2 --- 60.1 --- CAS 7631-86-9
Action and use: Excipient.
Colloidal Hydrated Silica BP Ph Eur Grade is also supplied:
CAS 63231-67-4
Action and use: Excipient.
Specifications of Silicon Dioxide FCC Food Grade:
Synthetic Amorphous Silica
SiO2 Formula weight 60.08
INS: 551 CAS 7631-86-9
DESCRIPTION
Silicon Dioxide occurs as an amorphous substance that shows a noncrystalline pattern when examined by X-ray diffraction. It is produced synthetically, either by a vapor-phase hydrolysisprocess, yielding fumed silica, or by a wet process, yielding precipitated silica, silica gel, colloidal silica, or hydrous silica. Fumed silica is produced in an essentially anhydrous state, whereas the wet-process products are obtained as hydrates or contain surface-adsorbed water.
Fumed silica occurs as a white, fluffy, nongritty powder of extremely fine particle size and is hygroscopic. The wet process silicas occur as white, fluffy powders or as white, microcellular beads or granules and are hygroscopic or absorb moisture from the air in varying amounts. All these forms of Silicon Dioxide are insoluble in water and in organic solvents but they are soluble in hydrofluoric acid and in hot, concentrated solutions of alkalies.
Function: Anticaking agent; defoaming agent; carrier; conditioning agent; chillproofing agent in malt beverages; filter aid.
REQUIREMENTS
Identification:
A. Place about 5 mg of sample into a platinum crucible, mix with 200 mg of anhydrous potassium carbonate and ignite over a burner at a red heat for about 10 min. Cool, dissolve the melt in 2 mL of freshly distilled water, warming if necessary, and slowly add 2 mL of ammonium molybdate. A deep yellow color appears.
B. Place 1 drop of the solution from Identification Test A on a filter paper and evaporate the solvent. Add 1 drop of a saturated solution of o-toluidine in glacial acetic acid and place the paper over ammonium hydroxide. A green-blue spot develops.
Assay: Fumed Silica: Not less than 99.0% of SiO2 after ignition; Precipitated Silica, Silica Gel, and Hydrous Silica: Not less than 94.0% of SiO2 after ignition.
Lead: Not more than 5 mg/kg.
Loss on Drying: Fumed Silica: Not more than 2.5%; Precipitated Silica and Silica Gel: Not more than 7.0%; Hydrous Silica: Not more than 70.0%; Colloidal Silica: Not more than 85.0%.
Loss on Ignition: Fumed Silica: Not more than 2.0% after drying; Silica Gel, Hydrous Silica, and Precipitated Silica: Not more than 8.5% after drying.
Soluble Ionizable Salts (as Na2SO4): Precipitated Silica, Silica Gel, and Hydrous Silica: Not more than 5.0%.
Please visit SDS Safety Data Sheet of Fumed Silica or Colloidal Silicon Dioxide and Precipitated Silica Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
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