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Calcium Saccharin
CAS Number: 6381-91-5 for Hydrate & 6485-34-3 for Anhydrous
Molecular Formula: C14H8CaN2O6S2-3.5H2O
Molecular Weight: 467.48
Calcium Saccharin
Saccharin Calcium USP Grade Specifications:
C14H8CaN2O6S2-3½ H2O - 467.48
C14H8CaN2O6S2 - 404.44
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, calcium salt, hydrate (2:7);
1,2-Benzisothiazolin-3-one 1,1-dioxide calcium salt hydrate (2:7) CAS 6381-91-5
Anhydrous CAS 6485-34-3
DEFINITION
Saccharin Calcium contains NLT 99.0% and NMT 101.0% of C14H8CaN2O6S2 , calculated on the anhydrous basis.
IDENTIFICATION
A. Infrared Absorption
Sample: Dry at 105C to constant weight.
B. Procedure
Sample solution: 100 mg/mL
Analysis: To the Sample solution add 2 drops of methyl red, and neutralize with 6 N ammonium hydroxide. Add 3 N hydrochloric acid, dropwise, until the solution is acid to the indicator. Add ammonium oxalat.
Acceptance criteria: A white precipitate is formed when the ammonium oxalate is added. This precipitate is insoluble in 6 N acetic acid but dissolves in hydrochloric acid.
C. Calcium salts moistened with hydrochloric acid impart a transient yellowish-red color to a nonluminous flame.
ASSAY
Procedure
Sample solution: 3 mg/mL of Saccharin Calcium in glacial acetic acid. [Note: Slight heating may be needed to dissolve the sample.]
Analysis: Titrate Sample solution with 0.1 N perchloric acid, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 20.22 mg of C14H8CaN2O6S2.
Acceptance criteria: 99.0%–101.0% on the anhydrous basis.
Impurity:
o-Toluenesulfonamide: 10 ppm maximum.
p-Toluenesulfonamide: 10 ppm maximum.
Procedure 2: Limit of Benzoate and Salicylate:
Sample solution: 50 mg/mL
Analysis: To 10 mL of the Sample solution add 5 drops of 6 N acetic acid and 3 drops of ferric chloride.
Acceptance criteria: No precipitate or violet color appears.
Water Determination: NMT 15.0%
Readily Carbonizable Substances:
Sample solution: 40 mg/mL in sulfuric acid (94.5%–95.5% (w/w) of H2SO4), 48C – 50C for 10 min
Acceptance criteria: The Sample solution has no more color than Matching Fluid A, when viewed against a white background.
Clarity of Solution: To pass the test.
Color of Solution: To pass the test.
Packaging and Storage: Preserve in well-closed containers. Store at room temperature.
Calcium Saccharin FCC Food Grade Specifications
1,2-Benzisothiazolin-3-one 1,1-Dioxide Calcium Salt
C14H8CaN2O6S2-31-2H2O Formula weight 467.48
INS: 954 CAS anhydrous 6485-34-3
DESCRIPTION
Calcium Saccharin occurs as white crystals or as a white, crystalline powder. One gram is soluble in 1.5 mL of water.
Function: Nonnutritive sweetener.
REQUIREMENTS
Identification:
A. Dissolve about 100 mg of sample in 5 mL of a 1:20 solution of sodium hydroxide, evaporate to dryness, and gently fuse the residue over a small flame until ammonia no longer evolves. After the residue has cooled, dissolve it in 20 mL of water, neutralize the solution with 2.7 N hydrochloric acid, and filter. Add 1 drop of ferric chloride to the filtrate. A violet color appears.
B. Mix 20 mg of sample with 40 mg of resorcinol, cautiously add 10 drops of sulfuric acid, and heat the mixture in a liquid bath at 200C for 3 min. After cooling, add 10 mL of water and an excess of 1 N sodium hydroxide. A fluorescent green liquid results.
C. A1:10 aqueous solution gives positive tests for Calcium.
D. Add 1 mL of hydrochloric acid to 10 mL of a 1:10 aqueous solution. A crystalline precipitate of saccharin forms. Wash the precipitate well with cold water, and dry at 105C for 2 h. The saccharin thus obtained melts between 226C and 230C.
Assay: Not less than 98.0% and not more than 101.0% of C14H8CaN2O6S2, calculated on the anhydrous basis.
Benzoate and Salicylate: Passes test.
Lead: Not more than 2 mg/kg.
Readily Carbonizable Substances: Passes test.
Selenium: Not more than 0.003%.
Toluenesulfonamides: Not more than 0.0025%.
Water: Not more than 15.0%.
Please visit SDS Safety Data Sheet of Calcium Saccharin Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
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