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Carbasalate Calcium BP Ph Eur Grade Supplier Exporter Manufacturers' Representative

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Carbasalate Calcium
CAS Number: 5749-67-7

Molecular Formula: C19H18CaN2O9
Molecular Weight: 458.4

Carbasalate Calcium Suppliers
Carbasalate Calcium

Carbasalate Calcium is not found in USP Monograph.

Carbasalate Calcium BP Ph Eur Grade Specifications
Ph Eur
C19H18CaN2O9 -- 458.4 -- CAS 5749-67-7

Equimolecular compound of calcium di[2-(acetyloxy)benzoate] and urea.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance).

Appearance: White or almost white, crystalline powder.
Solubility: Freely soluble in water and in dimethylformamide, practically insoluble in acetone and in anhydrous methanol.
Protect the substance from moisture during handling. Examination in aqueous solutions has to be performed immediately after preparation.

First identification: B, E.
Second identification: A, C, D, E.
A. Ultraviolet and visible absorption spectrophotometry.
Test solution: Dissolve 0.250 g in water and dilute to 100.0 ml with the same solvent. To 1.0 ml of the solution add 75 ml of water and 5 ml of dilute hydrochloric acid, mix and dilute to 100.0 ml with water. Examine immediately.
Spectral range: 220-350 nm.
Absorption maxima: At 228 nm and 276 nm.
Specific absorbances at the absorption maxima:
at 228 nm: 363 to 379,
at 276 nm: 49 to 53.
B. Infrared absorption spectrophotometry. Comparison: Ph. Eur. reference spectrum of carbasalate calcium.
C. Dissolve 0.1 g in 10 ml of water, boil for 2 min and cool. The solution gives reaction (a) of salicylates.
D. Heat 0.2 g with 0.2 g of sodium hydroxide; a yellow or yellowish-brown colour is produced and the vapour turns red litmus paper blue.
E. It gives reaction (a) of calcium.

Appearance of solution: The solution is not more opalescent than reference suspension II and is colourless.
Dissolve 2.5 g in 50 ml of water.
Related substances: Maximum 0.1 per cent, expressed as acetylsalicylsalicylic acid.
In a 100 ml volumetric flask, dissolve 0.150 g in 10 ml of 0.1 M tetrabutylammonium hydroxide in 2-propanol . Allow to stand for 10 min shaking occasionally. Add 8.0 ml of 0.1 M hydrochloric acid and 20.0 ml of a 19 g/l solution of disodium tetraborate and mix. While swirling continuously, add 2.0 ml of a 10 g/l solution of aminopyrazolone and 2.0 ml of a 10 g/l solution of potassium ferricyanide. Allow to stand for 2 min, dilute to 100.0 ml with water, mix and allow to stand for 20 min. Measure the absorbance of the solution at the absorption maximum at 505 nm using water as the compensation liquid. The absorbance is not greater than 0.125.
Impurity C: Maximum 0.5 per cent.
In a 100 ml volumetric flask, dissolve 0.200 g in 80 ml of water and add 10 ml of a 10 g/l solution of ferric nitrate in a 80 g/l solution of dilute nitric acid. Dilute to 100.0 ml with water. Immediately after preparation, measure the absorbance of the solution at the absorption maximum of 525 nm using water as the compensation liquid. The absorbance is not greater than 0.115.
Sodium: Maximum 0.10 per cent.
Heavy metals: Maximum 10 ppm.
Water: Maximum 0.1 per cent, determined on 1.000 g. Use a mixture of 15 ml of anhydrous methanol and 15 ml of dimethylformamide as the solvent.

Specified impurities: A, B, C.
A. 2-(acetyloxy)benzoic anhydride,
B. 2-[[2-(acetyloxy)benzoyl]oxy]benzoic acid (acetylsalicylsalicylic acid),
C. 2-hydroxybenzoic acid (salicylic acid).

Please visit SDS Safety Data Sheet of Carbasalate Calcium Suppliers.

American Molecules, also known as is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.

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Suppliers and Manufacturers' Representative:
American Molecules - USA
9910 Bent Oak Dr
Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665