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Benzalkonium Chloride Powder Solution
CAS Number: 8001-54-5 or 63449-41-2

Molecular Formula: Varies
Molecular Weight: Varies

Benzalkonium Chloride Powder Suppliers Benzalkonium Chloride Solution Suppliers
Benzalkonium Chloride Powder Solution

Benzalkonium Chloride USP Grade:
Ammonium, alkyldimethyl(phenylmethyl)-, chloride.
Alkylbenzyldimethylammonium chloride CAS 8001-54-5

Benzalkonium Chloride is a mixture of alkylbenzyldimethylammonium chlorides of the general formula: [C6H5CH2N(CH3)2R]Cl in which R represents a mixture of alkyls, including all or some of the group beginning with n-C8H17 and extending through higher homologs, with n-C12H25, n-C14H29, and n-C16H33 comprising the major portion. On the anhydrous basis, the content of the n-C12H25 homolog is not less than 40.0 percent, and the content of the n-C14H29 homolog is not less than 20.0 percent, of the total alkylbenzyldimethylammonium chloride content. The amounts of the n-C12H25 and n-C14H29 homolog components comprise together not less than 70.0 percent of the total alkylbenzyldimethylammonium chloride content. The total alkylbenzyldimethylammonium chloride content, calculated on the anhydrous basis, allowance being made for the amount of residue on ignition, is not less than 97.0 percent and not more than 103.0 percent of [C6H5CH2N(CH3)2R]Cl.

A: To a solution (1 in 100) add 2 N nitric acid or mercuric chloride TS: a white precipitate is formed, and it is soluble in alcohol.
B: Dissolve about 200 mg in 1 mL of sulfuric acid, add 100 mg of sodium nitrate, and heat on a steam bath for 5 minutes. Cool, dilute with water to 10 mL, add 500 mg of zinc dust, and warm for 5 minutes on a steam bath. To 2 mL of the clear supernatant add 1 mL of sodium nitrite solution (1 in 20), cool in ice water, then add 3 mL of a solution of 500 mg of 2-naphthol in 10 mL of 6 N ammonium hydroxide: an orange-red color is produced.
C: A solution of it in a mixture of equal volumes of water and alcohol responds to the tests for Chloride.
Water: not more than 15.0%.
Residue on ignition: not more than 2.0%.
Water-insoluble matter: A solution (1 in 10) is free from turbidity and insoluble matter.
Limit of foreign amines: To 5 mL of a solution (1 in 50) add 3 mL of 1 N sodium hydroxide: no precipitate is formed. Heat to boiling: the odor of amines is not perceptible.
Ratio of alkyl components: To pass the test.
Assay for total alkylbenzyldimethylammonium chlorides: Weigh accurately a quantity of Benzalkonium Chloride equivalent to about 500 mg of anhydrous benzalkonium chloride, and transfer, with the aid of 35 mL of water, to a glass-stoppered, 250-mL conical separator containing 25 mL of chloroform. Add 10.0 mL of freshly prepared potassium iodide solution (1 in 20), insert the stopper in the separator, shake, allow the layers to separate, and discard the chloroform layer. Wash the aqueous layer with three 10-mL portions of chloroform, and discard the washings. Transfer the aqueous layer to a glass-stoppered, 250-mL conical flask, and rinse the separator with three 5-mL portions of water, adding the washings to the flask. Add 40 mL of cold hydrochloric acid to the flask, mix, and titrate with 0.05 M potassium iodate VS until the solution becomes light brown in color. Add 5 mL of chloroform, insert the stopper into the flask, and shake vigorously. Continue the titration, dropwise, with shaking after each addition, until the chloroform layer becomes colorless and the aqueous layer is clear yellow. Perform a blank determination, using 20 mL of water as the sample. The difference between the two titrations represents the amount of potassium iodate equivalent to the weight of benzalkonium chloride in the sample. Each mL of 0.05 M potassium iodate is equivalent to x/10 mg of benzalkonium chloride,where x represents the average molecular weight of the sample, derived by summing, for all homologs, the products


where W is the molecular weight of a given homolog, A is the area of the peak produced by that homolog in the chromatogram from the Ratio of alkyl components test, and B is the total peak area for all homologs in that chromatogram.

Benzalkonium Chloride Solution USP Grade:
Benzalkonium Chloride Solution contains not less than 95.0 percent and not more than 105.0 percent of the labeled amount of benzalkonium chloride in concentrations of 1.0 percent or more; and not less than 93.0 percent and not more than 107.0 percent of the labeled amount in concentrations of less than 1.0 percent. It may contain a suitable coloring agent and may contain not more than 10 percent of alcohol.
Caution: Mixing Benzalkonium Chloride Solution with ordinary soaps and with anionic detergents may decrease or destroy the bacteriostatic activity of the Solution.

A: It responds to Identification tests A and C under Benzalkonium Chloride.
B: The residue obtained by evaporating, on a steam bath, a volume of Solution equivalent to about 200 mg of benzalkonium chloride responds to Identification test B under Benzalkonium Chloride.
Microbial limits: Solution containing less than 5.0% of benzalkonium chloride meets the requirements of the test for absence of Pseudomonas aeruginosa.
Alcohol content (if present): between 95.0% and 105.0% of the labeled amount of C2H5OH is found.
Limit of foreign amines: A volume of Solution, equivalent to 100 mg of benzalkonium chloride, and adjusted to a concentration of 1 in 50, meets the requirements of the test for Foreign amines under Benzalkonium Chloride.
Ratio of alkyl components: To pass the test.
Assay: Evaporate or dilute with water to about 30 mL an accurately measured volume of Solution, equivalent to about 275 mg of benzalkonium chloride. Transfer the solution with the aid of a minimum quantity of water to a glass-stoppered, 250-mL conical separator. Add 25 mL of chloroform, and proceed as directed in the Assay for total alkylbenzyldimethylammonium chlorides under Benzalkonium Chloride, beginning with “Add 10.0 mL of freshly prepared potassium iodide solution (1 in 20).”

We also supply Benzalkonium Chloride BP Ph Eur Grade.

Please visit SDS Safety Data Sheet of Benzalkonium Chloride Powder Solution Suppliers.

American Molecules, also known as is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.

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Suppliers and Manufacturers' Representative:
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Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665