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Cyanocobalamin or Vitamin B12 or 5,6-Dimethylbenzimidazolyl Cyanocobamide
CAS Number: 68-19-9
Molecular Formula: C63H88CoN14O14P
Molecular Weight: 1355.37
Cyanocobalamin or Vitamin B12 or 5,6-Dimethylbenzimidazolyl Cyanocobamide
Cyanocobalamin or Vitamin B12 or 5,6-Dimethylbenzimidazolyl Cyanocobamide the most common manufactured form of Vitamin B12. It has the a molecular weight of 1355.37 g/mol. It is widely used as a dietary supplement and medication to treat vitamin B12 deficiency.
Cyanocobalamin USP Grade Specifications:
C63H88CoN14O14P -- 1355.37
Vitamin B12 --- CAS 68-19-9
UNII: P6YC3EG204
DEFINITION
Cyanocobalamin contains NLT 96.0% and NMT 102.0% of cyanocobalamin (C63H88CoN14O14P), calculated on the dried basis.
IDENTIFICATION
A. Ultraviolet Absorption: To pass the test.
B.
Sample solution: Fuse 1 mg of Cyanocobalamin with 50 mg of potassium pyrosulfate in a porcelain crucible. Cool, break up the mass with a glass rod, add 3 mL of water, and dissolve by boiling.
Analysis: Add 1 drop of phenolphthalein and add sodium hydroxide solution (100 mg/mL), dropwise, until just pink. Add 500 mg of sodium acetate, 0.5 mL of 1 N acetic acid, and 0.5 mL of nitroso salt solution (2 mg/mL). Add 0.5 mL of hydrochloric acid, and boil for 1 min.
Acceptance criteria: A red or orange-red color appears immediately after the addition of nitroso salt. The red color persists after boiling with the addition of hydrochloric acid.
C. HPLC: To pass the test.
Related Compounds: To pass the test by Chromatography.
Loss on Drying:
Sample: 25 mg.
Analysis: Dry the Sample in a suitable vacuum drying apparatus at 105C and at a pressure of NMT 5 mm of mercury for 2 h.
Acceptance criteria: NMT 12.0%
Packaging and Storage: Preserve in tight, light-resistant containers, and store at controlled room temperature.
Vitamin B12 FCC Food Grade
Cyanocobalamin FCC Food Grade Specifications:
C63H88CoN14O14P Formula weight --- 1355.38
CAS 68-19-9
DESCRIPTION
Vitamin B12 occurs as dark red crystals or as an amorphous or crystalline powder. In the anhydrous form, it is very hygroscopic, and when exposed to air, it may absorb about 12% of water. It is sparingly soluble in water; soluble in alcohol; and insoluble in acetone, in chloroform, and in ether.
Function: Nutrient.
Identification:
A. The absorption spectrum of the Sample Solution used to measure absorbance in the Assay (below) exhibits maxima within _1 nm at 278 nm and 361 nm, and within _2 nm at 550 nm. The ratio A361/A278 is between 1.70 and 1.90, and the ratio A361/A550 is between 3.15 and 3.40.
B. Fuse about 1 mg of sample with about 50 mg of potassium pyrosulfate in a porcelain crucible, cool, and break up the mass with a glass rod. Add 3 mL of water, and dissolve by boiling. Add 1 drop of phenolphthalein, mix, and then add drops of a 1:10 solution of sodium hydroxide until just pink. Add 500 mg of sodium acetate, 0.5 mL of 1 N acetic acid, and 0.5 mL of a 1:500 solution of nitroso salt. A red or orange-red color appears at once. Add 0.5 mL of hydrochloric acid, and boil for 1 min. The red color persists.
C. Dissolve about 5 mg of sample in 5 mL of water contained in a 50-mL distilling flask connected to a short, watercooled, vertical condenser, the tip of which dips into a test tube containing 1 mL of a 1:50 solution of sodium hydroxide. Add 2.5 mL of hypophosphorous acid to the flask, then close the flask, heat at simmering for 10 min, and distill 1 mL into the test tube. Add 4 drops of cold, saturated ferrous ammonium sulfate solution to the tube, shake gently, then add about 30 mg of sodium fluoride, and bring the contents to a boil. Immediately add drops of 1:7 sulfuric acid until a clear solution results, and then add 3 to 5 drops more of the acid. A blue or blue-green color appears within a few minutes.
Assay: Not less than 96.0% and not more than 100.5% of C63H88CoN14O14P, calculated on the dried basis.
Loss on Drying: Not more than 12.0%.
Pseudo Cyanocobalamin: Passes test.
We also offer Cyanocobalamin or Vitamin B12 or 5,6-Dimethylbenzimidazolyl Cyanocobamide BP Ph Eur Grade as per the monograph.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
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